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KMID : 0370219880320010020
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Yakhak Hoeji
1988 Volume.32 No. 1 p.20 ~ p.25
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Development and Structural Activity Relationship of New Local Anti-inflammatory Steroid, Prednisolone Derivatives
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Abstract
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New prednisolone derivatives including methyl 2R-acetoxy-prednisolonate have been synthesized and evaluated for local anti-inflammatory agents with reduced systemic side effect. Methyl 20p-dihydroprednisolonate and methyl 20E-acetoxyprednisolonate showed comparable anti-inflammtory activity in vivo with significantly reduced systemic side effects.
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